Osteoarthritis (OA) is a common degenerative joint disease that affects millions of people worldwide, causing pain, stiffness, and reduced joint function. As pharmacists, it is vital to stay updated on the latest treatment options to provide comprehensive care to patients. Two natural compounds, avocado-soybean unsaponifiables (ASU) and Boswellia, have gained significant attention for their potential benefits in managing OA. Here we explore the therapeutic properties, mechanisms of action, and clinical evidence supporting the use of ASU and Boswellia in osteoarthritis...